Mrs. Holland was born and raised in Huntsville, Alabama. She attended the University of Alabama in Huntsville and graduated in 1980 with a Bachelor's of Science Degree in Nursing. She specialized in Oncology nursing and left nursing in 1992 to begin teaching Health Science at the Madison County Career Technical Center. In 2006, she came to Sparkman High School and along with Mrs. Goins, started the Medical Academy.
Mrs. Holland has been married to Fred since 1979 and has one child, Anna Key, who is married and works as a Registered Dietitian at Huntsville Hospital. Mrs. Holland has one grand-daughter - Evie - who is the light of her life.